Concordance of common movement disorders among familial cases
Identifieur interne : 002044 ( Main/Exploration ); précédent : 002043; suivant : 002045Concordance of common movement disorders among familial cases
Auteurs : Rajput [Canada] ; M. E. Fenton [Canada] ; D. George [Canada] ; Alex Rajput [États-Unis] ; W. Wilson [Canada] ; L. Mcculloch [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-09.
English descriptors
Abstract
Multicase families are frequently utilized in studies of movement disorders (MDs). We report families with two or more MD cases seen at the Movement Disorder Clinic, Saskatoon (MDCS). In 30% of the MD probands, there was either a history or documentation of at least one secondary MD case in the family. Only those MD cases that were seen at the MDCS were considered in this study. A total of 56 probands and 77 secondary MD cases were seen at the MDCS between 1968 and 1996. In 24 (31.2%) of the secondary cases, the diagnosis was different from that in the proband. In 46 families (82%), only one secondary case was seen, and the diagnosis was concordant with the proband in 71.7%. In the remaining 10 families with two or more secondary cases, the diagnosis was concordant in 64.5% of cases. The largest subgroup was Parkinson's disease (PD)—40 probands and 53 secondary cases. Of these secondary cases, 73.6% had PD. The concordance rate was 91% in essential tremor, but only 12.5% if the proband had essential tremor + parkinsonism. Considering that a large proportion of secondary cases have a diagnosis discordant with the proband, we recommend that, wherever possible, MD diagnosis in secondary cases be based on clinical assessment.
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DOI: 10.1002/mds.870120520
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-09">1997-09</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="747">747</biblScope><biblScope unit="page" to="751">751</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">73D6BBFD94DB0284705AD346CD3CBC87A70E95C2</idno><idno type="DOI">10.1002/mds.870120520</idno><idno type="ArticleID">MDS870120520</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Familial movement disorders</term><term>Movement disorder concordance</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multicase families are frequently utilized in studies of movement disorders (MDs). We report families with two or more MD cases seen at the Movement Disorder Clinic, Saskatoon (MDCS). In 30% of the MD probands, there was either a history or documentation of at least one secondary MD case in the family. Only those MD cases that were seen at the MDCS were considered in this study. A total of 56 probands and 77 secondary MD cases were seen at the MDCS between 1968 and 1996. In 24 (31.2%) of the secondary cases, the diagnosis was different from that in the proband. In 46 families (82%), only one secondary case was seen, and the diagnosis was concordant with the proband in 71.7%. In the remaining 10 families with two or more secondary cases, the diagnosis was concordant in 64.5% of cases. The largest subgroup was Parkinson's disease (PD)—40 probands and 53 secondary cases. Of these secondary cases, 73.6% had PD. The concordance rate was 91% in essential tremor, but only 12.5% if the proband had essential tremor + parkinsonism. Considering that a large proportion of secondary cases have a diagnosis discordant with the proband, we recommend that, wherever possible, MD diagnosis in secondary cases be based on clinical assessment.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Rajput" sort="Rajput" uniqKey="Rajput" last="Rajput">Rajput</name></noRegion><name sortKey="Fenton, M E" sort="Fenton, M E" uniqKey="Fenton M" first="M. E." last="Fenton">M. E. Fenton</name><name sortKey="George, D" sort="George, D" uniqKey="George D" first="D." last="George">D. George</name><name sortKey="Mcculloch, L" sort="Mcculloch, L" uniqKey="Mcculloch L" first="L." last="Mcculloch">L. Mcculloch</name><name sortKey="Wilson, W" sort="Wilson, W" uniqKey="Wilson W" first="W." last="Wilson">W. Wilson</name></country><country name="États-Unis"><region name="Iowa"><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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